Babymouse discovers Squish, a new species of amoeba, while working on a school science fair project.

Squish, a meek amoeba who loves the comic book exploits of his favorite hero, "Super Amoeba," tries to emulate him when his best friend is threatened by a bully.

Squish the amoeba neglects his homework, parents, friends, and even his Super Amoeba comic books when he discovers the video game Mitosis.

Squish the amoeba's friend Pod has been feeling strange lately, but Squish finds out Pod is going through mitosis, the process that splits single-celled organisms.

At swim camp, Squish's new friend Basil helps him avoid learning to swim with pranks that sometimes go too far, but the comic book exploits of Squish's idol, "Super Amoeba," help him deal with Basil and conquer his fear.