Pursued by her much older brother, famed detective Sherlock Holmes, fourteen-year-old Enola, disguised and using false names, attempts to solve the kidnapping of a baronet's sixteen-year-old daughter in nineteenth-century London.

While fourteen-year-old Enola Holmes endeavors to save her friend Lady Cecily Alistair from an unwelcome arranged marriage, she meets with some assistance from her older brother, Sherlock, and interference by the eldest, Mycroft.

In late nineteenth-century London, fourteen-year-old Enola Holmes, much younger sister of detective Sherlock Holmes, turns to Florence Nightingale for help when her investigation into the disappearance of a Crimean War widow grows cold.

Pursued by her much older brother, famed detective Sherlock Holmes, fourteen-year-old Enola, disguised and using false names, attempts to solve the kidnapping of a baronet's sixteen-year-old daughter in nineteenth-century London.